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The Chemistry of Ozone Therapy on Cancer

Ozone therapy is the safest and most effective cancer therapy I have ever found. An interesting aspect of ozone therapy is that ozone has the ability to selectively destroy cancer cells without damaging healthy tissue.
See: http://www.ncbi.nlm.nih.gov/pubmed/7403859

Science. 1980 Aug 22;209(4459):931-3.

Ozone selectively inhibits growth of human cancer cells.
Sweet F, Kao MS, Lee SC, Hagar WL, Sweet WE.


The growth of human cancer cells from lung, breast, and uterine tumors was selectively inhibited in a dose-dependent manner by ozone at 0.3 to 0.8 part per million of ozone in ambient air during 8 days of culture. Human lung diploid fibroblasts served as noncancerous control cells. The presence of ozone at 0.3 to 0.5 part per million inhibited cancer cell growth 40 and 60 percent, respectively. The noncancerous lung cells were unaffected at these levels. Exposure to ozone at 0.8 part per million inhibited cancer cell growth more than 90 percent and control cell growth less than 50 percent. Evidently, the mechanisms for defense against ozone damage are impaired in human cancer cells.

Another interesting aspect of ozone when dealing with cancer is that the ozone fights cancer through a variety of mechanisms. Some of the anticancer effects of ozone include:

  • Destruction of cancer producing pathogens.
  • Oxidative destruction of xenoestrogens and other carcinogens.
  • Increasing levels of immune stimulating and cancer fighting cytokines.
  • Increasing levels of superoxide dismutase (SOD). SOD converts the superoxide anion in to oxygen, and anti-cancer and immune stimulating hydrogen peroxide.
  • Increasing white blood cell activity.
  • Decreasing lactate levels preventing its conversion back in to glucose through gluconeogenesis.
  • Immediate and direct destruction of cancer cells through an overload of peroxide within the cancerous cells.

Advantages of ozone over allopathic treatments include:

  • Cancerous cells cannot build up a tolerance to ozone the way it can to chemotherapy or radiation therapy. This is especially useful for destroying metastasized cells that can migrate in to the brain or bone where they are hard to treat with allopathic methods.
  • Ozone therapy is not inhibited by a poor vasculature within tumors as is the case with chemotherapy and radiation therapy, which is why these therapies have such low success rates.
  • Ozone therapy does not cause metastases of cancer cells like biopsies and radiation therapy can.
  • Ozone therapy is not carcinogenic (cancer causing) or immune suppressing like radiation therapy and chemotherapy.
  • Ozone stimulates the healing of damaged tissues in low concentrations.
  • Ozone treatments can be self administered at home.
  • Ozone therapy is cost efficient. Cold corona units needed for therapy can be purchased for between $500-1500, with an additional $200 for an oxygen tank and regulator. The cost of oxygen and electricity averages less than $0.10 per treatment.

To understand how ozone directly destroys cancer cells we first need to go over some basic chemistry. Ozone is generally accepted as being O3, although higher allotropes (O4 and up) do exist. If I write up the formula this way O:O·O we can see that two of the oxygen atoms are stable due to paired electrons, but the third oxygen atom is not. This makes the ozone molecule itself unstable and reactive. As the ozone molecule is broken down singlet oxygen (O1 or O·) is formed. Singlet oxygen is one of the strongest oxidizers known, with only fluorine exceeding it in oxidation power.

The oxygen we breath, O2, is stable because it has paired balancing electrons (O:O). Singlet oxygen (O·) on the other hand does not have a paired electron to stabilize it. This makes the singlet oxygen highly reactive since it is needs to seek out an electron it can steal so it can stabilize itself. For example, as ozone breaks down the singlet oxygen atoms released can react with each other to form a more stable O2.

Other sources for singlet oxygen to obtain electrons from to stabilize can include carcinogens, cancer microbes, water and lipids (fats). It is this reactivity that allows ozone to have so many anticancer properties.
These anticancer properties include:

  • Killing cancer pathogens by either reacting with the lipids in the membranes of the pathogen creating lipid peroxides destroying the pathogen directly, or by reacting with water to form hydrogen peroxide that in turn destroys the pathogen.
  • Destruction of carcinogens, such as xenoestrogens through oxidative destruction by ozone.
  • Peroxides formed by ozone increase production of immune supporting cytokines.
  • Peroxides created by the reaction of ozone on water lead to cellular apoptosis (self destruction) of low adenosine triphosphate (ATP) containing cells such as aged cells and cancerous tumor cells.
  • Both lipid peroxides and hydrogen peroxide created during ozone therapy increase white blood activity, which are a primary component of the immune system.
  • The formation of lipid and hydrogen peroxides lead to the selective destruction of cancerous tumor cells through an overload of peroxide within the cells.

Before I go any further though, I need to point out a key difference between cancerous tumor cells and healthy cells. This will help explain how ozone selectively kills cancer cells.

Healthy cells contain antioxidant enzymes known as catalase (CAT), glutathione peroxidases that break down peroxides to protect healthy cells from oxidative damage by these peroxides.

Peroxides though are required for a number of functions within the body. These functions include destruction of pathogens, activation of white blood cells, stimulating production of immune enhancing cytokines and destruction of cancerous cells by natural killer (NK) cells.

Cancerous cells are often hard for the immune system to detect since they can “shield” themselves from the immune system to avoid detection. When the immune system is able to detect cancerous tumor cells, NK cells attach to the cells. Once attached NK cells inject peroxide in to these cancerous cells. Unlike healthy cells though, cancerous cells lack sufficient levels of CAT and peroxidases. This is an Achilles’ heel for cancerous cells. Because cancerous cells are deficient in these enzymes peroxide entering the cancer cells will swell these cancer cells to the point of rupturing. This selectively kills the cancer cells without destroying healthy cells since healthy cells contain sufficient levels of these enzymes to break down the peroxides harmlessly in to water and oxygen.

Ozone has a very similar effect on cancer cells as NK cells. When ozone reacts with the lipids (fats) of cancer cell membranes lipid peroxides are formed. Singlet oxygen formed from the breakdown of ozone will also form some hydrogen peroxide by reaction with extracellular water. These peroxides enter cancer cells causing the cancer cells to swell until they burst. During the process more singlet oxygen is generated, which in turn creates more peroxides leading to a chain reaction. Therefore, very small amounts of ozone are capable of destroying extensive amounts of cancer cells upon contact.

One study performed in Germany found that when ozone was injected in to mammary carcinomas of mice that the tumors were completely destroyed within 5 minutes of injection. There was no damage to surrounding healthy tissue.

Ozone therapy must be properly administrated with the proper dosage for the therapy to be safe and effective. Therefore, ozone therapy should not be applied without proper knowledge and training.

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